| # | Player | Runs | Balls Faced | 4s | 6s | SR | Against | Venue | Date |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Evin Lewis | 125 | 62 | 6 | 12 | 201.61 | India | Kingston | 09-Jul-2017 |
| 2 | Johnson Charles | 118 | 46 | 10 | 11 | 256.52 | South Africa | Centurion | 26-Mar-2023 |
| 3 | Chris Gayle | 117 | 57 | 7 | 10 | 205.26 | South Africa | Johannesburg | 11-Sep-2007 |
| 4 | Rovman Powell | 107 | 53 | 4 | 10 | 201.88 | England | Bridgetown | 26-Jan-2022 |
| 5 | Chris Gayle | 100 | 48 | 5 | 11 | 208.33 | England | Wankhede | 16-Mar-2016 |
| 6 | Evin Lewis | 100 | 49 | 5 | 9 | 204.08 | India | Lauderhill | 27-Aug-2016 |
| 7 | Chris Gayle | 98 | 66 | 5 | 7 | 148.48 | India | Bridgetown | 09-May-2010 |
| 8 | Nicholas Pooran | 98 | 53 | 6 | 8 | 184.90 | Afghanistan | Gros Islet | 17-Jun-2024 |
| 9 | Lendl Simmons | 91 | 40 | 5 | 10 | 227.50 | Ireland | Basseterre | 19-Jan-2020 |
| 10 | Evin Lewis | 91 | 51 | 5 | 9 | 178.43 | Pakistan | Port of Spain | 01-Apr-2017 |
| 11 | Chris Gayle | 90 | 41 | 9 | 7 | 219.51 | South Africa | Johannesburg | 11-Jan-2015 |
| 12 | Marlon Samuels | 89 | 66 | 9 | 3 | 134.84 | Afghanistan | Basseterre | 05-Jun-2017 |
| 13 | Evin Lewis | 89 | 36 | 6 | 8 | 247.22 | Bangladesh | Mirpur | 22-Dec-2018 |
| 14 | Chris Gayle | 88 | 50 | 6 | 6 | 176.00 | Australia | The Oval | 06-Jun-2009 |
| 15 | Chris Gayle | 85 | 52 | 7 | 5 | 163.46 | New Zealand | Lauderhill | 30-Jun-2012 |
| 16 | Marlon Samuels | 85 | 43 | 3 | 9 | 197.67 | Bangladesh | Mirpur | 10-Dec-2012 |
| 17 | Marlon Samuels | 85 | 66 | 9 | 2 | 128.78 | England | Eden Gardens | 03-Apr-2016 |
| 18 | Brandon King | 85 | 55 | 5 | 6 | 154.54 | India | Lauderhill | 13-Aug-2023 |
| 19 | Andre Fletcher | 84 | 64 | 6 | 5 | 131.25 | Sri Lanka | Bengaluru | 20-Mar-2016 |
| 20 | Johnson Charles | 84 | 56 | 10 | 3 | 150.00 | England | Pallekele | 27-Sep-2012 |
| 21 | Lendl Simmons | 82 | 51 | 7 | 5 | 160.78 | India | Wankhede | 31-Mar-2016 |
| 22 | Brandon King | 82 | 52 | 8 | 5 | 157.69 | England | St George's | 14-Dec-2023 |
| 23 | Shai Hope | 82 | 39 | 4 | 8 | 210.25 | U.S.A. | Bridgetown | 21-Jun-2024 |
| 24 | Nicholas Pooran | 82 | 45 | 6 | 6 | 182.22 | England | St George's | 16-Dec-2023 |
| 25 | Shimron Hetmyer | 81 | 54 | 8 | 4 | 150.00 | Sri Lanka | Abu Dhabi | 04-Nov-2021 |
| 26 | Johnson Charles | 79 | 33 | 6 | 7 | 239.39 | India | Lauderhill | 27-Aug-2016 |
| 27 | Evin Lewis | 79 | 34 | 4 | 9 | 232.35 | Australia | Gros Islet | 16-Jul-2021 |
| 28 | Brandon King | 79 | 45 | 6 | 6 | 175.55 | South Africa | Kingston | 23-May-2024 |
| 29 | Marlon Samuels | 78 | 56 | 3 | 6 | 139.28 | Sri Lanka | Colombo (RPS) | 07-Oct-2012 |
| 30 | Lendl Simmons | 77 | 50 | 12 | 1 | 154.00 | South Africa | The Oval | 13-Jun-2009 |
| 31 | Chris Gayle | 77 | 31 | 5 | 8 | 248.38 | South Africa | Cape Town | 09-Jan-2015 |
| 32 | Chris Gayle | 75 | 41 | 5 | 6 | 182.92 | Australia | Colombo (RPS) | 05-Oct-2012 |
| 33 | Kieron Pollard | 75 | 37 | 4 | 8 | 202.70 | New Zealand | Auckland | 27-Nov-2020 |
| 34 | Nicholas Pooran | 74 | 39 | 5 | 5 | 189.74 | Bangladesh | Providence | 07-Jul-2022 |
| 35 | Kyle Mayers | 73 | 50 | 8 | 4 | 146.00 | India | Basseterre | 02-Aug-2022 |
| 36 | Dwayne Smith | 72 | 43 | 10 | 3 | 167.44 | Bangladesh | Mirpur | 25-Mar-2014 |
| 37 | Lendl Simmons | 72 | 48 | 10 | 2 | 150.00 | Australia | Gros Islet | 14-Jul-2021 |
| 38 | Evin Lewis | 71 | 35 | 4 | 7 | 202.85 | South Africa | St George's | 26-Jun-2021 |
| 39 | Andre Russell | 71 | 29 | 4 | 7 | 244.82 | Australia | Perth | 13-Feb-2024 |
| 40 | Dwayne Smith | 70 | 54 | 5 | 5 | 129.62 | England | Nottingham | 24-Jun-2012 |
| 41 | Nicholas Pooran | 70 | 43 | 4 | 5 | 162.79 | England | Bridgetown | 26-Jan-2022 |
| 42 | Marlon Samuels | 69 | 46 | 10 | 1 | 150.00 | England | Bridgetown | 09-Mar-2014 |
| 43 | Lendl Simmons | 69 | 55 | 7 | 2 | 125.45 | England | Bridgetown | 13-Mar-2014 |
| 44 | Johnson Charles | 69 | 26 | 9 | 5 | 265.38 | South Africa | Kingston | 26-May-2024 |
| 45 | Rovman Powell | 68 | 36 | 4 | 5 | 188.88 | India | Eden Gardens | 18-Feb-2022 |
| 46 | Sherfane Rutherford | 68 | 39 | 2 | 6 | 174.35 | New Zealand | Tarouba | 12-Jun-2024 |
| 47 | Evin Lewis | 68 | 41 | 4 | 6 | 165.85 | Afghanistan | Lucknow | 14-Nov-2019 |
| 48 | Kieron Pollard | 68 | 39 | 5 | 6 | 174.35 | India | Wankhede | 11-Dec-2019 |
| 49 | Brandon King | 68 | 52 | 8 | 2 | 130.76 | India | Basseterre | 01-Aug-2022 |
| 50 | Evin Lewis | 68 | 31 | 4 | 7 | 219.35 | England | Gros Islet | 16-Nov-2024 |
| 51 | Lendl Simmons | 67 | 45 | 4 | 4 | 148.88 | India | Thiruvananthapuram | 08-Dec-2019 |
| 52 | Lendl Simmons | 67 | 51 | 7 | 2 | 131.37 | Sri Lanka | Pallekele | 04-Mar-2020 |
| 53 | Sherfane Rutherford | 67 | 40 | 5 | 5 | 167.50 | Australia | Perth | 13-Feb-2024 |
| 54 | Roston Chase | 67 | 38 | 7 | 2 | 176.31 | South Africa | Kingston | 25-May-2024 |
| 55 | Chris Gayle | 67 | 41 | 5 | 5 | 163.41 | New Zealand | Auckland | 26-Dec-2008 |
| 56 | Chris Gayle | 67 | 38 | 4 | 7 | 176.31 | Australia | Gros Islet | 12-Jul-2021 |
| 57 | Brandon King | 67 | 43 | 6 | 3 | 155.81 | Pakistan | Karachi | 14-Dec-2021 |
| 58 | Nicholas Pooran | 67 | 40 | 6 | 4 | 167.50 | India | Providence | 06-Aug-2023 |
| 59 | DJ Bravo | 66 | 36 | 4 | 3 | 183.33 | India | Lord's | 12-Jun-2009 |
| 60 | Nicholas Pooran | 65 | 26 | 2 | 7 | 250.00 | South Africa | Tarouba | 23-Aug-2024 |
| 61 | Lendl Simmons | 65 | 44 | 7 | 2 | 147.72 | Pakistan | Gros Islet | 21-Apr-2011 |
| 62 | Nicholas Pooran | 64 | 37 | 2 | 6 | 172.97 | Pakistan | Karachi | 16-Dec-2021 |
| 63 | Chris Gayle | 63 | 50 | 8 | 2 | 126.00 | Sri Lanka | The Oval | 19-Jun-2009 |
| 64 | Kieron Pollard | 63 | 29 | 5 | 5 | 217.24 | New Zealand | Lauderhill | 30-Jun-2012 |
| 65 | Lendl Simmons | 63 | 49 | 1 | 6 | 128.57 | Zimbabwe | North Sound | 02-Mar-2013 |
| 66 | Dwayne Smith | 63 | 34 | 6 | 4 | 185.29 | Australia | Bridgetown | 30-Mar-2012 |
| 67 | Rovman Powell | 63 | 36 | 5 | 4 | 175.00 | Australia | Adelaide | 11-Feb-2024 |
| 68 | Brandon King | 63 | 33 | 11 | 1 | 190.90 | Sri Lanka | Dambulla | 13-Oct-2024 |
| 69 | Nicholas Pooran | 62 | 33 | 4 | 6 | 187.87 | Pakistan | Providence | 31-Jul-2021 |
| 70 | Brandon King | 62 | 48 | 6 | 1 | 129.16 | Ireland | Hobart | 21-Oct-2022 |
| 71 | Andre Fletcher | 62 | 49 | 3 | 3 | 126.53 | New Zealand | Roseau | 06-Jul-2014 |
| 72 | Nicholas Pooran | 62 | 41 | 5 | 3 | 151.21 | India | Eden Gardens | 18-Feb-2022 |
| 73 | Rovman Powell | 61 | 28 | 2 | 6 | 217.85 | Bangladesh | Roseau | 03-Jul-2022 |
| 74 | DS Smith | 61 | 34 | 7 | 3 | 179.41 | England | The Oval | 28-Jun-2007 |
| 75 | Chris Gayle | 61 | 37 | 8 | 1 | 164.86 | England | The Oval | 29-Jun-2007 |